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Cell. 2008 Jul 25;134(2):212-4. doi: 10.1016/j.cell.2008.07.010.

SIRT1 is a circadian deacetylase for core clock components.

Author information

1
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.

Abstract

The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.

PMID:
18662537
PMCID:
PMC3671948
DOI:
10.1016/j.cell.2008.07.010
[Indexed for MEDLINE]
Free PMC Article

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