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Brain Pathol. 2009 Oct;19(4):573-85. doi: 10.1111/j.1750-3639.2008.00195.x. Epub 2008 Jul 25.

Brain extracellular matrix in neurodegeneration.

Author information

1
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA.

Abstract

The role of extracellular matrix (ECM) in neurological development, function and degeneration has evolved from a simplistic physical adhesion to a system of intricate cellular signaling. While most cells require ECM adhesion to survive, it is now clear that differentiated function is intimately dependent upon cellular interaction with the ECM. Therefore, it is not surprising that the ECM is increasingly found to be involved in the enigmatic process of neurodegeneration. Descriptive studies of human neurodegenerative disorders and experimental studies of animal models of neurodegeneration have begun to define potential mechanisms of ECM disruption that can lead to synaptic and neuronal loss.

PMID:
18662234
PMCID:
PMC2742568
DOI:
10.1111/j.1750-3639.2008.00195.x
[Indexed for MEDLINE]
Free PMC Article

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