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Connect Tissue Res. 2008;49(3):219-24. doi: 10.1080/03008200802143356.

Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer.

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Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.


Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. In this review we provide evidence that the hyaluronan-ErbB2-PI3kinase/AKT-ss-catenin-COX-2 signaling axis leads to intestinal epithelial and colon tumor cell division and proliferation. This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer.

[Indexed for MEDLINE]

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