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Exp Gerontol. 2009 Jan-Feb;44(1-2):106-11. doi: 10.1016/j.exger.2008.05.003. Epub 2008 May 17.

Age-related muscle dysfunction.

Author information

1
Department of Physical Medicine and Rehabilitation, University of Minnesota, MMC 388, 420 Delaware Street, S.E., Minneapolis, MN 55455, USA. thomp067@umn.edu

Abstract

Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction.

PMID:
18657920
PMCID:
PMC4074082
DOI:
10.1016/j.exger.2008.05.003
[Indexed for MEDLINE]
Free PMC Article

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