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Cancer Lett. 2008 Dec 8;272(1):23-31. doi: 10.1016/j.canlet.2008.06.014. Epub 2008 Jul 26.

A stem cell gene expression profile of human squamous cell carcinomas.

Author information

1
Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom.

Abstract

To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

PMID:
18657901
PMCID:
PMC2580815
DOI:
10.1016/j.canlet.2008.06.014
[Indexed for MEDLINE]
Free PMC Article

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