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Mol Cell. 2008 Jul 25;31(2):153-65. doi: 10.1016/j.molcel.2008.06.013.

How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.

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Department of Molecular Biology and NCCR Frontiers in Genetics Program, University of Geneva, Sciences III, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Geneva, Switzerland.


The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerase-promoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.

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