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Ageing Res Rev. 2008 Jul;7(3):234-48. doi: 10.1016/j.arr.2008.04.003. Epub 2008 May 4.

Oscillatory signaling and network responses during the development of Dictyostelium discoideum.

Author information

1
Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-8028, USA.

Abstract

Periodic biological variations reflect interactions among molecules and cells, or even organisms. The Dictyostelium cAMP oscillatory circuit is a highly robust example. cAMP oscillations in Dictyostelium arise intracellularly by a complex interplay of activating and inhibiting pathways, are transmitted extracellularly, and synchronize an entire local population. Once established, cAMP signal-relay persists stably for hours. On a two-dimensional surface, >100,000 cells may form a single coordinated territory. In suspension culture, >10(10) cells can oscillate in harmony. This review focuses on molecular mechanisms that cyclically activate and attenuate signal propagation and on chemotactic responses to oscillatory wave progression.

PMID:
18657484
PMCID:
PMC5155118
DOI:
10.1016/j.arr.2008.04.003
[Indexed for MEDLINE]
Free PMC Article

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