Format

Send to

Choose Destination
Seizure. 2009 Jan;18(1):34-7. doi: 10.1016/j.seizure.2008.06.010. Epub 2008 Jul 25.

Vagus nerve stimulation in pediatric epileptic syndromes.

Author information

1
Hôpital Sainte-Justine, Département de neurologie pédiatrique, Canada.

Abstract

Vagal nerve stimulation (VNS) has shown promising results in various cohorts of non-surgical refractory epilepsy in adults and children. However studies report a significant delay between implantation and clinical response. We describe a cohort of 28 children and adolescents prospectively followed, classified by epileptic syndromes and treated with VNS using a 6-week rapid ramping protocol between January 2000 and March 2005. Our cohort showed favorable outcome within 6 months which was sustained at 24 months: 68% (19/28) showing >or=50% reduction in seizure frequency, including 14% (4/28) who became seizure-free. VNS was particularly efficacious in children with cryptogenic generalized and partial epilepsies. Although adverse events occurred in 68% (19/28) of patients, most were transient. In conclusion, rapid ramping is associated with an early and lasting response in most children but with a slightly higher side-effect rate.

PMID:
18657451
DOI:
10.1016/j.seizure.2008.06.010
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center