Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2008 Jun;18(3):276-83. doi: 10.1016/j.conb.2008.06.005.

Nerve injury signaling.

Author information

  • 1Department of Anatomy and Neurobiology, Washington University in St. Louis, 660 S Euclid Avenue, St. Louis, MO 63110-1093, USA.

Abstract

Although neurons within the peripheral nervous system (PNS) have a remarkable ability to repair themselves after injury, neurons within the central nervous system (CNS) do not spontaneously regenerate. This problem has remained recalcitrant despite a century of research on the reaction of axons to injury. The balance between inhibitory cues present in the environment and the intrinsic growth capacity of the injured neuron determines the extent of axonal regeneration following injury. The cell body of an injured neuron must receive accurate and timely information about the site and extent of axonal damage in order to increase its intrinsic growth capacity and successfully regenerate. One of the mechanisms contributing to this process is retrograde transport of injury signals. For example, molecules activated at the injury site convey information to the cell body leading to the expression of regeneration-associated genes and increased growth capacity of the neuron. Here we discuss recent studies that have begun to dissect the injury-signaling pathways involved in stimulating the intrinsic growth capacity of injured neurons.

PMID:
18655834
PMCID:
PMC2633416
DOI:
10.1016/j.conb.2008.06.005
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center