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Neuropharmacology. 2009 Jan;56(1):2-5. doi: 10.1016/j.neuropharm.2008.06.063. Epub 2008 Jul 4.

A nomenclature for ligand-gated ion channels.

Author information

  • 1MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. g.l.collingridge@bristol.ac.uk

Abstract

The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely, to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues.

PMID:
18655795
PMCID:
PMC2847504
DOI:
10.1016/j.neuropharm.2008.06.063
[PubMed - indexed for MEDLINE]
Free PMC Article
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