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Int J Food Sci Nutr. 2009;60 Suppl 3:1-13. doi: 10.1080/09637480802232625. Epub 2009 Jul 24.

Effects of two energy-restricted diets differing in the carbohydrate/protein ratio on weight loss and oxidative changes of obese men.

Author information

1
Department of Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.

Abstract

INTRODUCTION:

Low-carbohydrate, high-protein diets are a current challenge in the nutritional treatment of obesity.

OBJECTIVE:

To compare the effect of a low-carbohydrate high-protein diet with a traditional hypocaloric diet on weight loss and mitochondrial oxidative metabolism.

SUBJECTS AND METHODS:

Nineteen obese men (age 36+/-6 years; body mass index 34+/-2 kg/m2) were randomized to follow one of the two diets-control diet (15% protein; 30% lipids; 55% carbohydrates) or high-protein diet (30% protein; 30% lipids; 40% carbohydrates)-over an 8-week period. Anthropometry, biochemical variables, resting energy expenditure and mitochondrial oxidation were measured at the start and at the end of the intervention.

RESULTS:

The high-protein diet produced a greater weight loss (-8.3+/-1.2% versus -5.5+/-2.5%, P = 0.012) than the control diet. Interestingly, an activation in the mitochondrial oxidation was found in the high-protein-fed group. This stimulation was positively correlated with the final resting energy expenditure and negatively associated with the final fat mass content.

CONCLUSION:

Low-carbohydrate high-protein diets could involve specific changes in mitochondrial oxidation that could be related to a higher weight loss.

PMID:
18654910
DOI:
10.1080/09637480802232625
[Indexed for MEDLINE]

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