Send to

Choose Destination
See comment in PubMed Commons below
Mult Scler. 2008 Nov;14(9):1280-3. doi: 10.1177/1352458508094643. Epub 2008 Jul 24.

Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis.

Author information

  • 1Keele Multiple Sclerosis Research Group, Department of Neurology, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire, UK.


Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G(1229), C/G(3444), G/A(3944), CC(20965), CC(30056), F/f(30875), C/T(48200), T/t(65013)) with outcome or disability. ff(30875) frequency was lower in cases with EDSS > or = 6.0 than with scores < 6.0 (odds ratio = 0.38, 95% CI = 0.20-0.70). The association of ff(30875) with outcome was not mediated by cumulative exposure to UVR as assessed by questionnaire; low exposure (odds ratio = 0.42, 95% CI = 0.14-1.34) and high exposure (odds ratio = 0.34, 95% CI = 0.16-0.73).

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center