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Res Microbiol. 2008 Jun;159(5):332-9. doi: 10.1016/j.resmic.2008.04.008. Epub 2008 May 7.

Comparative genomics of the mycobacteriophages: insights into bacteriophage evolution.

Author information

1
Department of Biological Sciences and Pittsburgh Bacteriophage Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA. gfh@pitt.edu

Abstract

The recognition of the vast numbers of bacteriophages in the biosphere has prompted a renewal of interest in understanding their morphological and genetic diversity, and elucidating the evolutionary mechanisms that give rise to them. We have approached these questions by isolating and characterizing a collection of mycobacteriophages that infect a common bacterial host, Mycobacterium smegmatis. Comparative genomic analysis of 50 mycobacteriophages shows that they are highly diverse, although not uniformly so, that they are pervasively mosaic with a multitude of single gene modules, and that this mosaicism is generated through illegitimate recombination.

PMID:
18653319
PMCID:
PMC2632949
DOI:
10.1016/j.resmic.2008.04.008
[Indexed for MEDLINE]
Free PMC Article

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