Send to

Choose Destination
Dig Dis Sci. 2008 Sep;53(9):2307-12. doi: 10.1007/s10620-008-0413-9. Epub 2008 Jul 24.

The association between obesity and GERD: a review of the epidemiological evidence.

Author information

The Sections of Gastroenterology and Health Services Research, The Houston Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USA.


The current epidemics of obesity and gastroesophageal reflux disease (GERD)-related disorders have generated much interest in studying the association between them. Results of multiple studies indicate that obesity satisfies several criteria for a causal association with GERD and some of its complications, including a generally consistent association with GERD symptoms, erosive esophagitis, and esophageal adenocarcinoma. An increase in GERD symptoms has been shown to occur in individuals who gain weight but continue to have a body mass index (BMI) in the normal range, contributing to the epidemiological evidence for a possible dose-response relationship between BMI and increasing GERD. Data are less clear on the relationship between Barrett's esophagus (BE) and obesity. However, when considered separately, abdominal obesity seems to explain a considerable part of the association with GERD, including BE. Overall, epidemiological data show that maintaining a normal BMI may reduce the likelihood of developing GERD and its potential complications.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center