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Lab Chip. 2008 Aug;8(8):1262-4. doi: 10.1039/b805456h. Epub 2008 Jun 13.

Controlled encapsulation of single-cells into monodisperse picolitre drops.

Author information

1
Massachusetts General Hospital, BioMEMS Resource Center, Charlestown, MA, USA.

Abstract

Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation.

PMID:
18651066
PMCID:
PMC2570196
DOI:
10.1039/b805456h
[Indexed for MEDLINE]
Free PMC Article
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