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Nature. 2008 Jul 24;454(7203):463-9. doi: 10.1038/nature07206.

The role of exercise and PGC1alpha in inflammation and chronic disease.

Author information

1
Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, CH-8057 Zurich, Switzerland. christoph.handschin@access.uzh.ch

Abstract

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

PMID:
18650917
PMCID:
PMC2587487
DOI:
10.1038/nature07206
[Indexed for MEDLINE]
Free PMC Article

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