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Br J Cancer. 2008 Aug 5;99(3):392-7. doi: 10.1038/sj.bjc.6604483. Epub 2008 Jul 22.

Tumour-targeted nanomedicines: principles and practice.

Author information

1
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, Utrecht 3584 CA, The Netherlands.

Abstract

Drug targeting systems are nanometre-sized carrier materials designed for improving the biodistribution of systemically applied (chemo)therapeutics. Various different tumour-targeted nanomedicines have been evaluated over the years, and clear evidence is currently available for substantial improvement of the therapeutic index of anticancer agents. Here, we briefly summarise the most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines.

PMID:
18648371
PMCID:
PMC2527811
DOI:
10.1038/sj.bjc.6604483
[Indexed for MEDLINE]
Free PMC Article

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