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Invest Radiol. 2008 Aug;43(8):574-9. doi: 10.1097/RLI.0b013e31817fb432.

Microbleeds in moyamoya disease: susceptibility-weighted imaging versus T2*-weighted imaging at 3 Tesla.

Author information

1
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Abstract

OBJECTIVES:

To prospectively evaluate differences in detectability of cerebral microbleeds (MBs) in Moyamoya disease (MMD) on susceptibility-weighted imaging (SWI) and T2*-weighted imaging (T2*WI) at 3 T.

MATERIALS AND METHODS:

SWI and T2*WI were applied for 50 consecutive MMD patients. MB was defined as a very low signal intensity area in each sequence without continuity from surrounding vessel structures. Numbers of MBs were compared between the 2 sequences. To assess visualization, a grading score was assigned to each MB from Grade 3 (prominent) to Grade 0 (normal-appearing) on SWI and T2*WI, respectively, and were compared by Wilcoxon signed rank test.

RESULTS:

A total of 37 MBs were detected in 21 patients (42%) on SWI, compared with 27 MBs in 16 patients (32%) on T2*WI, with significant difference in number of MBs between the 2 sequences (P = 0.002). Lesions displayed greater visual grading score on SWI than on T2*WI (P < 0.0001).

CONCLUSIONS:

SWI offers better detectability of MBs in MMD than T2*WI at 3 T.

PMID:
18648257
DOI:
10.1097/RLI.0b013e31817fb432
[Indexed for MEDLINE]

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