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Br J Dermatol. 2008 Sep;159(4):804-10. doi: 10.1111/j.1365-2133.2008.08745.x. Epub 2008 Jul 21.

Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin.

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1
Genomics Research Centre, School of Medical Science, Griffith University, Gold Coast, Parklands Drive, Southport, Qld 9726, Australia.

Abstract

BACKGROUND:

Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene.

OBJECTIVES:

We investigated polymorphisms within the VDR gene for association with solar keratosis (SK), a biomarker for skin cancer, and examined interactions with skin phenotype.

METHODS:

Among participants of the community-based Nambour Skin Cancer Study, we genotyped 190 people with SKs and 190 without for ApaI, TaqI and FokI polymorphisms.

RESULTS:

We found a significant difference in genotype frequencies of the TaqI polymorphism between affected and unaffected populations (P = 0.008). The TT/tt genotype group was associated with a twofold increase in odds of being affected by one or more SK. Individuals with fair skin and the TT/tt genotype had about a sevenfold increase, whereas fair-skinned people with the Tt genotype had a fourfold increase in odds of being affected by SK. Individuals with the TT/tt genotype who were prone to burn and not tan on acute sun exposure had about a sixfold increase in odds of SK. Fair-skinned people with VDR-Apa AA/aa genotypes had about an eightfold increase in odds of being affected by SK compared with a fivefold increase in individuals with the Aa genotype and fair skin.

CONCLUSIONS:

The trend for homozygote genotypes to increase the odds of SK suggests that intermediate VDR activity is important in protection or that the heterodimer formed by a heterozygous genotype may have an altered binding potential. Overall, these analyses indicate that VDR may be important in SK development.

[Indexed for MEDLINE]

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