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J Clin Periodontol. 2008 Sep;35(9):817-24. doi: 10.1111/j.1600-051X.2008.01295.x. Epub 2008 Jul 21.

Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration.

Author information

1
Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands. anton.sculean@gmx.de

Abstract

BACKGROUND:

Surgery utilizing an enamel matrix protein derivative (EMD) or guided tissue regeneration (GTR) has been shown to promote periodontal regeneration.

AIM:

To evaluate the 10-year results following treatment with EMD, GTR, EMD+GTR, and open flap debridement (OFD).

MATERIAL AND METHODS:

Thirty-eight patients out of an initial group of 56 participants were treated with one of the four modalities. Results were evaluated before surgery, at 1 year, and at 10 years. Primary outcome variable was CAL change.

RESULTS:

Treatment with EMD yielded a mean CAL gain of 3.4+/-1.0 mm (p<0.001) and 2.9+/-1.4 mm (p<0.001) at 1 and 10 years, respectively. GTR resulted in a mean CAL gain of 3.2+/-1.4 (p<0.001) at 1 year and 2.8+/-1.2 mm (p<0.001) at 10 years. Mean CAL gain in the EMD+GTR group was of 3.3+/-1.1 mm (p<0.001) and 2.9+/-1.2 mm (p<0.001) at 1 and 10 years, respectively. Treatment with OFD demonstrated a mean CAL gain of 2.0+/-1.2 mm (p<0.01) at 1 year and 1.8+/-1.1 mm (p<0.01) at 10 years. Compared with OFD, the three regenerative treatments resulted in statistically significant (p<0.05) higher CAL gain, at both 1 and 10 years. The CAL change between 1 and 10 years did not present statistically significant differences in any of the four groups.

CONCLUSION:

The present results indicate that the clinical outcomes obtained with all four approaches can be maintained over a period of 10 years.

[Indexed for MEDLINE]

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