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J Proteome Res. 2008 Sep;7(9):3765-75. doi: 10.1021/pr800042n. Epub 2008 Jul 23.

Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility.

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Graduate Institute of Biomedical Sciences, Proteomics Core Laboratory, Molecular Medicine Research Center, Department of Cell and Molecular Biology, Department of Public Health, Chang Gung University, Tao-Yuan, Taiwan.


Oral squamous cell carcinoma (OSCC) is the 11th most common cancer worldwide, and is associated with a high death rate. At present, there are no suitable markers for detecting and/or monitoring OSCC in body fluids/tissues. Here, we used 1D SDS-PAGE and MALDI-TOF MS to systematically analyze the secretomes of two OSCC cell lines (OEC-M1 and SCC4). The putative OSCC-related proteins identified in this analysis included the Mac-2 binding protein (Mac-2 BP), which was further found to be overexpressed in OSCC specimens and significantly elevated in the sera of OSCC patients compared to healthy controls. Finally, RNA interference-based knock-down of Mac-2 BP expression in OSCC cells revealed for the first time that Mac-2 BP is involved in regulating growth and motility of OSCC cells.

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