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Mol Cancer Ther. 2008 Jul;7(7):2142-51. doi: 10.1158/1535-7163.MCT-08-0005.

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.

Author information

1
Nemours Center for Childhood Cancer Research, Alfred I. DuPont Hospital for Children, Rockland Center I, 1701 Rockland Road, Wilmington, DE 19803, USA.

Erratum in

  • Mol Cancer Ther. 2008 Sep;7(9):3122. Ryazantsev, Sergey [added].

Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane protein highly expressed in advanced and metastatic prostate cancers. The pathologic consequence of elevated PSMA expression in not known. Here, we report that PSMA is localized to a membrane compartment in the vicinity of mitotic spindle poles and associates with the anaphase-promoting complex (APC). PSMA-expressing cells prematurely degrade cyclin B and exit mitosis due to increased APC activity and incomplete inactivation of APC by the spindle assembly checkpoint. Further, expression of PSMA in a karyotypically stable cell line induces aneuploidy. Thus, these findings provide the first evidence that PSMA has a causal role in the induction of aneuploidy and might play an etiologic role in the progression of prostate cancer.

PMID:
18645024
PMCID:
PMC2548318
DOI:
10.1158/1535-7163.MCT-08-0005
[Indexed for MEDLINE]
Free PMC Article

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