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Mol Cancer Ther. 2008 Jul;7(7):2142-51. doi: 10.1158/1535-7163.MCT-08-0005.

Prostate-specific membrane antigen associates with anaphase-promoting complex and induces chromosomal instability.

Author information

Nemours Center for Childhood Cancer Research, Alfred I. DuPont Hospital for Children, Rockland Center I, 1701 Rockland Road, Wilmington, DE 19803, USA.

Erratum in

  • Mol Cancer Ther. 2008 Sep;7(9):3122. Ryazantsev, Sergey [added].


Prostate-specific membrane antigen (PSMA) is a transmembrane protein highly expressed in advanced and metastatic prostate cancers. The pathologic consequence of elevated PSMA expression in not known. Here, we report that PSMA is localized to a membrane compartment in the vicinity of mitotic spindle poles and associates with the anaphase-promoting complex (APC). PSMA-expressing cells prematurely degrade cyclin B and exit mitosis due to increased APC activity and incomplete inactivation of APC by the spindle assembly checkpoint. Further, expression of PSMA in a karyotypically stable cell line induces aneuploidy. Thus, these findings provide the first evidence that PSMA has a causal role in the induction of aneuploidy and might play an etiologic role in the progression of prostate cancer.

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