Format

Send to

Choose Destination
Eur J Surg Oncol. 2009 Apr;35(4):339-47. doi: 10.1016/j.ejso.2008.06.006. Epub 2008 Jul 21.

MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

Author information

1
University Surgical Unit, Level F Centre Block, Southampton General Hospital, Southampton, UK. ahm@soton.ac.uk

Abstract

MicroRNAs (miRNAs) represent a recently uncovered class of small and endogenous non-coding RNAs. MiRNA function is critical to normal cellular processes such as differentiation and apoptosis, and recent studies have demonstrated that deregulated miRNA expression contributes to the malignant phenotype. The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide.

PMID:
18644693
DOI:
10.1016/j.ejso.2008.06.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center