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Neurobiol Aging. 2010 Apr;31(4):721-2. doi: 10.1016/j.neurobiolaging.2008.05.030. Epub 2008 Jul 21.

LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation.

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1
Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada. Connie.marras@utoronto.ca

Abstract

Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone.

[Indexed for MEDLINE]

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