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Dev Biol. 1991 Aug;146(2):353-63.

Simultaneous maturation of transverse tubules and sarcoplasmic reticulum during muscle differentiation in the mouse.

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1
Department of Anatomy, University of Pennsylvania, Philadelphia 19104-6058.

Abstract

The development and maturation of transverse (T) tubules and sarcoplasmic reticulum (SR) have been studied in pre- and postnatal mouse muscle, using selective "staining" of these membrane systems. As previously reported in the literature, orderly transverse orientation of the T tubules occurs late in development and early T-SR junctions (triads and dyads) are located at random along the T tubules in a predominantly longitudinal orientation. We find that initial appearance of transverse tubules occurs fairly abruptly, and that all early T tubules have a longitudinal orientation. Transverse orientation of the T tubule network, location of triads at the A-I junction, and development of differentiated regions of the SR are coordinated events which occur gradually over a period of about 3 weeks for leg muscle.s The timing of triad development coincides with that reported for the increase in slow calcium current and dihydropyridine binding. Differences in T tubule patterns between muscle fibers of EDL and soleus are apparent only at relatively late stages.

PMID:
1864461
DOI:
10.1016/0012-1606(91)90237-w
[Indexed for MEDLINE]

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