Format

Send to

Choose Destination
Curr Opin Microbiol. 2008 Aug;11(4):369-77. doi: 10.1016/j.mib.2008.06.004. Epub 2008 Jul 31.

Structural proteomics of dengue virus.

Author information

1
Markey Center for Structural Biology & Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, United States.

Abstract

In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the recently solved structures of NS5 methyltransferase and polymerase domains. These structures provide a basis for describing function and predicting putative host interactions.

PMID:
18644250
PMCID:
PMC2581888
DOI:
10.1016/j.mib.2008.06.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center