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Phys Rev Lett. 2008 Jun 13;100(23):238102. Epub 2008 Jun 13.

Single cell mechanics: stress stiffening and kinematic hardening.

Author information

1
Experimentalphysik I, Physikalisches Institut, Universität Bayreuth, Bayreuth, Germany.

Abstract

Cell mechanical properties are fundamental to the organism but remain poorly understood. We report a comprehensive phenomenological framework for the complex rheology of single fibroblast cells: a superposition of elastic stiffening and viscoplastic kinematic hardening. Despite the complexity of the living cell, its mechanical properties can be cast into simple, well-defined rules. Our results reveal the key role of crosslink slippage in determining mechanical cell strength and robustness.

PMID:
18643547
DOI:
10.1103/PhysRevLett.100.238102
[Indexed for MEDLINE]

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