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J Am Chem Soc. 2008 Aug 13;130(32):10492-3. doi: 10.1021/ja8039019. Epub 2008 Jul 22.

Isostructural self-assembly of 2'-deoxyguanosine derivatives in aqueous and organic media.

Author information

1
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico.

Abstract

We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.

PMID:
18642917
PMCID:
PMC2646872
DOI:
10.1021/ja8039019
[Indexed for MEDLINE]
Free PMC Article

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