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Org Lett. 2008 Aug 21;10(16):3643-5. doi: 10.1021/ol801425v. Epub 2008 Jul 19.

Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.

Author information

1
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Abstract

Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.

PMID:
18642835
PMCID:
PMC2659505
DOI:
10.1021/ol801425v
[Indexed for MEDLINE]
Free PMC Article

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