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Hybridoma (Larchmt). 2008 Apr;27(2):65-9.

A natural human IgM antibody that neutralizes botulinum neurotoxin in vivo.

Author information

1
Cardeza Foundation for Hematologic Research and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Abstract

Affinity-matured human antibodies have demonstrated efficacy as countermeasures for exposure to botulinum neurotoxin (BoNT), which is the cause of the disease botulism category A select bioterror agent. Little is known, however, about the potential role of natural (un-mutated) antibodies in the protective immune response to BoNT. Here we describe the cloning of two human IgM antibodies that bind serotype A BoNT. Both are un-mutated IgM antibodies, consistent with an origin in naive B cells. One of the antibodies is able to fully neutralize a lethal dose of serotype A BoNT in vivo. These results suggest that the natural human antibody repertoire may play a role in protection from exposure to biological toxins.

PMID:
18642670
DOI:
10.1089/hyb.2007.0549
[Indexed for MEDLINE]
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