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Arq Neuropsiquiatr. 2008 Jun;66(2B):303-7.

Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex.

Author information

1
Department of Radiology, University of Parana, Curitiba, PR, Brazil. arnolfocarvalho@hotmail.com

Abstract

PURPOSE:

To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC).

METHOD:

Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant.

RESULTS:

There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05).

CONCLUSION:

The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.

PMID:
18641860
[Indexed for MEDLINE]
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