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J Biosci Bioeng. 2008 Jun;105(6):675-8. doi: 10.1263/jbb.105.675.

Inhibition of mitochondrial fragmentation during sake brewing causes high malate production in sake yeast.

Author information

1
National Research Institute of Brewing, Higashi-hiroshima City, Hiroshima, Japan. kitagaki@nrib.go.jp

Abstract

We previously demonstrated the presence and fragmentation of mitochondria during alcohol fermentation. Here, we show that Fis1p induces mitochondrial fragmentation, and inhibition of mitochondrial fragmentation causes higher malate production during sake brewing. These findings indicate that mitochondrial morphology affects the metabolism of constituents, providing a breeding strategy for high-malate-producing yeasts.

PMID:
18640610
DOI:
10.1263/jbb.105.675
[Indexed for MEDLINE]

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