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J Proteomics. 2008 Aug 21;71(3):357-67. doi: 10.1016/j.jprot.2008.07.001. Epub 2008 Jul 9.

Quantitative proteomics as a new piece of the systems biology puzzle.

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DIBIT, San Raffaele Scientific Institute, Milan, Italy.


The definition of the role of each gene product in its cellular context is of outstanding importance in the post-genomics era. Recent technological innovations have driven research in proteomics from single protein characterization to global approaches, aiming to achieve a comprehensive qualitative and quantitative description of complex molecular mechanisms. In this review, we discuss the methodology of quantitative proteomics as it applies to the analysis of complex biological model systems. A special attention will be given to model systems that are suitable for functional genomic studies, where the potential of quantitative proteomics can be effectively demonstrated.

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