Format

Send to

Choose Destination
See comment in PubMed Commons below
Phys Med Biol. 2008 Aug 7;53(15):4203-12. doi: 10.1088/0031-9155/53/15/013. Epub 2008 Jul 17.

Noninvasive photoacoustic imaging of the developing vasculature during early tumor growth.

Author information

1
MOE Key Laboratory of Laser Life Science, South China Normal University, Guangzhou 510631, People's Republic of China.

Abstract

In this study, we monitor the progress of vasculature in early tumor growth using photoacoustic imaging over a 20 day period after subcutaneous inoculation of breast cancer tumor cells in a mouse. With 532 nm laser pulses employed as an irradiation source, the photoacoustic images were obtained through the photoacoustic signals received by a hydrophone in orthogonal mode. The morphological characteristics of vasculature in tumor region are clearly resolved in the photoacoustic images, and the change in structure as well as the increase in density can be identified. Moreover, the average photoacoustic signal strength of vasculature in tumor region, which is highly correlated with the total hemoglobin concentration of blood, is enhanced during early tumor growth. These results indicate the feasibility of detecting early stage tumor and monitoring the progress of anti-angiogenic therapy by photoacoustic imaging.

PMID:
18635896
DOI:
10.1088/0031-9155/53/15/013
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IOP Publishing Ltd.
    Loading ...
    Support Center