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Science. 2008 Jul 18;321(5887):342; author reply 342. doi: 10.1126/science.1158766.

Comment on "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea".

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  • 1Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, S-752 36 Sweden.


Berg et al. (Reports, 14 December 2007, p. 1782) reported the discovery of an autotrophic carbon dioxide-fixation pathway in Archaea and implicated a substantial role of this pathway in global carbon cycling based on sequence analysis of Global Ocean Sampling data. We question the validity of the latter claim.

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