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Endocrinology. 2008 Nov;149(11):5706-12. doi: 10.1210/en.2008-0717. Epub 2008 Jul 17.

Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.

Author information

1
Institut National de la Santé et de la Recherche Médicale, Unité 834, Montpellier F-34298, France.

Abstract

Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4-/- mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases.

PMID:
18635652
PMCID:
PMC2605582
DOI:
10.1210/en.2008-0717
[Indexed for MEDLINE]
Free PMC Article

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