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Anesth Analg. 2008 Jul;107(1):167-70. doi: 10.1213/ane.0b013e3181732dc2.

The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study.

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1
Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

Abstract

BACKGROUND:

Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.

METHODS:

This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.

RESULTS:

Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.

CONCLUSION:

This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.

PMID:
18635484
DOI:
10.1213/ane.0b013e3181732dc2
[Indexed for MEDLINE]
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