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Clin Vaccine Immunol. 2008 Sep;15(9):1429-35. doi: 10.1128/CVI.00169-08. Epub 2008 Jul 16.

Oral immunization with recombinant lactobacillus plantarum induces a protective immune response in mice with Lyme disease.

Author information

1
Department of Microbiology and Immunology, New York Medical College, Valhalla, New York,USA.

Abstract

Mucosal immunization is advantageous over other routes of antigen delivery because it can induce both mucosal and systemic immune responses. Our goal was to develop a mucosal delivery vehicle based on bacteria generally regarded as safe, such as Lactobacillus spp. In this study, we used the Lyme disease mouse model as a proof of concept. We demonstrate that an oral vaccine based on live recombinant Lactobacillus plantarum protects mice from tick-transmitted Borrelia burgdorferi infection. Our method of expressing vaccine antigens in L. plantarum induces both systemic and mucosal immunity after oral administration. This platform technology can be applied to design oral vaccine delivery vehicles against several microbial pathogens.

PMID:
18632920
PMCID:
PMC2546682
DOI:
10.1128/CVI.00169-08
[Indexed for MEDLINE]
Free PMC Article

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