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J Neurophysiol. 2008 Sep;100(3):1562-75. doi: 10.1152/jn.90613.2008. Epub 2008 Jul 16.

Effect of synaptic connectivity on long-range synchronization of fast cortical oscillations.

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Department of Cell Biology and Neuroscience, University of California, Riverside, Riverside, CA 92521, USA.

Erratum in

  • J Neurophysiol. 2008 Dec;100(6):3460.


Cortical gamma oscillations in the 20- to 80-Hz range are associated with attentiveness and sensory perception and have strong connections to both cognitive processing and temporal binding of sensory stimuli. These gamma oscillations become synchronized within a few milliseconds over distances spanning a few millimeters in spite of synaptic delays. In this study using in vivo recordings and large-scale cortical network models, we reveal a critical role played by the network geometry in achieving precise long-range synchronization in the gamma frequency band. Our results indicate that the presence of many independent synaptic pathways in a two-dimensional network facilitate precise phase synchronization of fast gamma band oscillations with nearly zero phase delays between remote network sites. These findings predict a common mechanism of precise oscillatory synchronization in neuronal networks.

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