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FEMS Immunol Med Microbiol. 2008 Oct;54(1):1-17. doi: 10.1111/j.1574-695X.2008.00454.x. Epub 2008 Jul 8.

Exported proteins in probiotic bacteria: adhesion to intestinal surfaces, host immunomodulation and molecular cross-talking with the host.

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  • 1Laboratoire de Microbiologie et Biochimie Appliquée, UMR 5248 CBMN CNRS-Université Bordeaux 1-ENITAB, 33175 Gradignan Cedex, France.


The group of exported proteins of a bacterium are those proteins that are sorted from the cytoplasm to the bacterial surface or to the surroundings of the microorganism. In probiotic bacteria, these proteins are of special relevance because they might determine important traits such as adhesion to intestinal surfaces and molecular cross-talking with the host. Current knowledge about the presence and biological relevance of exported proteins produced by the main genera of probiotic bacteria in the gastrointestinal environment is reviewed in this minireview. As will be seen, some of these proteins are involved in host adhesion or are able to modify certain signalization pathways within host cells, whereas others are important for the physiology of probiotic bacteria in the gastrointestinal tract.

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