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Biochem Soc Trans. 2008 Aug;36(Pt 4):698-700. doi: 10.1042/BST0360698.

UPF1 P-body localization.

Author information

  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. s.brogna@bham.ac.uk

Abstract

NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm. However, recent studies have indicated that the core NMD factors UPF1 (up-frameshift-1), UPF2 and UPF3 can associate with P-bodies (processing bodies), which are large cytoplasmic granules replete with proteins involved in general mRNA decay and related processes. It has been proposed that UPF1 directs PTC-containing mRNAs to P-bodies and triggers decay. Here, we discuss the link between P-bodies and NMD in view of recent studies that suggest that P-bodies are not required for NMD in Drosophila.

PMID:
18631143
DOI:
10.1042/BST0360698
[PubMed - indexed for MEDLINE]

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