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Comp Funct Genomics. 2001;2(3):169-75. doi: 10.1002/cfg.81.

Definition of the gene content of the human genome: the need for deep experimental verification.

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The Ludwig Institute for Cancer Research, Rua Professor Antônio Prudente 109, São Paulo, SP 01509-010, Brazil.


Based on the analysis of the drafts of the human genome sequence, it is being speculated that our species may possess an unexpectedly low number of genes. The quality of the drafts, the impossibility of accurate gene prediction and the lack of sufficient transcript sequence data, however, render such speculations very premature. The complexity of human gene structure requires additional and extensive experimental verification of transcripts that may result in major revisions of these early estimates of the number of human genes.

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