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J Cutan Med Surg. 2008 Jul-Aug;12(4):184-8.

Long-term management of generalized pustular psoriasis with infliximab: case series.

Author information

1
Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, USA.

Abstract

BACKGROUND:

Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.

OBJECTIVE:

The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.

METHODS:

Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.

RESULTS:

Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.

CONCLUSION:

Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.

PMID:
18627699
DOI:
10.2310/7750.2008.07036
[Indexed for MEDLINE]

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