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Curr HIV/AIDS Rep. 2008 Aug;5(3):140-9.

Non-AIDS-defining malignancies among HIV-infected patients in the highly active antiretroviral therapy era.

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1
VA North Texas Health Care System and University of Texas Southwestern Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA. roger.bedimo@utsouthwestern.edu

Abstract

In the highly active antiretroviral therapy (HAART) era, the incidence of AIDS-defining malignancies (ADMs) has declined significantly. On the other hand, the incidence of other malignancies not known to be associated with immunosuppression (non-ADMs) has not changed and remains significantly higher than in the general population. Some recent controlled studies even suggest that the incidence of selected non-ADMs has increased in the HAART era. These trends warrant a high index of suspicion for malignancies among HIV care providers and a renewed focus on understanding the mechanisms underlying the increased rates. Potential explanations for the higher non-ADM rates include longer survival of patients with HIV on HAART, with only partial immune recovery achieved in most patients; high incidence of human papillomavirus, Epstein-Barr virus, and hepatitis C virus coinfection in patients with HIV infection; and potential oncogenicity of long-term HIV infection or of long-term HAART.

PMID:
18627663
[Indexed for MEDLINE]
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