Format

Send to

Choose Destination
Dev Dyn. 2008 Aug;237(8):2081-9. doi: 10.1002/dvdy.21620.

Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos.

Author information

1
Graduate School of Medicine, Korea University, Ansan, Gyeonggido, Republic of Korea.

Abstract

During vertebrate neural development, many dividing neuroepithelial precursors adopt features of radial glia, which are now known to also serve as neural precursors. In mammals, most radial glia do not persist past early postnatal stages, whereas zebrafish maintain large numbers of radial glia into adulthood. The mechanisms that maintain and specify radial glia for different fates are still poorly understood. We investigated formation of radial glia in the spinal cord of zebrafish and the role of Notch signaling in their maintenance and specification. We found that spinal cord precursors begin to express gfap+, a marker of radial glia, during neurogenesis and that gfap cells give rise to both neurons and oligodendrocytes. We also determined that Notch signaling is continuously required during embryogenesis to maintain radial glia, limit motor neuron formation and permit oligodendrocyte development, but that radial glia seem to be refractory to changes in Notch activity in postembryonic animals.

PMID:
18627107
PMCID:
PMC2646814
DOI:
10.1002/dvdy.21620
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center