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J Comp Neurol. 2008 Sep 20;510(3):237-50. doi: 10.1002/cne.21746.

Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development.

Author information

1
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

It is widely accepted that the process of retinal cell fate determination is under tight transcriptional control mediated by a combinatorial code of transcription factors. However, the exact repertoire of factors necessary for the genesis of each retinal cell type remains to be fully defined. Here we show that the HMG-box transcription factor, Sox9, is expressed in multipotent mouse retinal progenitor cells throughout retinogenesis. We also find that Sox9 is downregulated in differentiating neuronal populations, yet expression in Müller glial cells persists into adulthood. Furthermore, by employing a conditional knockout approach, we show that Sox9 is essential for the differentiation and/or survival of postnatal Müller glial cells.

PMID:
18626943
PMCID:
PMC4412477
DOI:
10.1002/cne.21746
[Indexed for MEDLINE]
Free PMC Article

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