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Cell Res. 2008 Aug;18(8):807-16. doi: 10.1038/cr.2008.83.

PTEN: a default gate-keeping tumor suppressor with a versatile tail.

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1
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In this review, we briefly discuss recent advances concerning PTEN regulation and how such knowledge facilitates our understanding and further exploration of PTEN biology. The carboxyl-tail of PTEN, which appears to be associated with multiple types of posttranslational regulation, will be under detailed scrutiny. Further, a comparative analysis of PTEN and p53 suggests while p53 needs to be activated to suppress tumorigenesis (a dormant gatekeeper), PTEN is probably a constitutive surveillant against cancer development, thus a default gatekeeper.

PMID:
18626510
DOI:
10.1038/cr.2008.83
[Indexed for MEDLINE]
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