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Kidney Int. 2008 Aug;74(3):259-61. doi: 10.1038/ki.2008.260.

Glomerular filtration: the charge debate charges ahead.

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  • 1Renal Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

Abstract

The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.

PMID:
18626493
DOI:
10.1038/ki.2008.260
[PubMed - indexed for MEDLINE]
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