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J Cell Mol Med. 2008 Sep-Oct;12(5A):1432-44. doi: 10.1111/j.1582-4934.2008.00399.x. Epub 2008 Jul 8.

MicroRNA expression in lymphoid malignancies: new hope for diagnosis and therapy?

Author information

1
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. charles.lawrie@ndcls.ox.ac.uk

Abstract

MicroRNAs are a newly discovered class of short (approximately 22 nt) naturally occurring single-stranded RNA molecules that regulate the expression of target genes post-transcriptionally. Despite only being discovered 7 years ago, microRNAs have been implicated as key regulatory molecules in nearly every biological process examined so far and abnormal expression of microRNAs have been linked to many forms of disease including cancer where they can function as both tumour-suppressors and oncogenes. So why are microRNAs causing so much excitement? And will this excitement translate into new medical breakthroughs? This review attempts to answer these questions in the wider context of cancer, focusing on the role that microRNAs play in normal lymphoid development and malignancy.

PMID:
18624758
PMCID:
PMC3918059
DOI:
10.1111/j.1582-4934.2008.00399.x
[Indexed for MEDLINE]
Free PMC Article

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