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Transplantation. 2008 Jul 15;86(1):1-9. doi: 10.1097/TP.0b013e31817c11e6.

The multiple facets of toll-like receptors in transplantation biology.

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1
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.

Abstract

Toll-like receptors (TLRs) belong to a family of pattern-recognition receptors for microbial products and endogenous molecules released by stressed cells. Experimental studies show that TLRs are involved in the process of acute allograft rejection and that their activation can prevent transplantation tolerance. Herein, we review the expression of TLRs and the impact of TLR signaling in different cell types in grafted organs including antigen-presenting cells, T and B lymphocytes, epithelial and endothelial cells. We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses.

PMID:
18622268
PMCID:
PMC4423792
DOI:
10.1097/TP.0b013e31817c11e6
[Indexed for MEDLINE]
Free PMC Article
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